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Daisy M. Silanno

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Opposing Effects of Alcohol on the Immune System PMC

If you’re unfamiliar, inflammation is what naturally occurs when your immune system goes into action. The redness and swelling that you see is the result of your body sending more blood to provide nutrients to the site of injury. “There are multiple studies that show people with low zinc are more susceptible to infection,” added Dr. LeComte. To boost your immunity, stock up on foods that have anti-inflammatory effects on the body. Messaoudi says that even once heavy drinking stops, researchers still see “immunological scars” from that heavy drinking at least three months later. Weekly intimacy seems to help boost your immune system compared to those who have it less often.

does alcohol lower immunity

On the one hand, alcohol impairs the trafficking of zona occludens (ZO)-1 and occludin, both proteins of tight junctions [209]. On the other hand, patients with alcoholic liver disease display increased intestinal levels of miR-212 that in turn binds the ZO-1 mRNA and impedes its synthesis [210]. The subsequent increased gut permeability enables the translocation of viable bacteria and their metabolites, toxins, and further DAMPs and PAMPs from intraintestinal lumen into extrainestinal space, reaching the liver by circulation, where it contributes to development of alcoholic liver disease [211,212].

Alcohol Use As a Risk Factor in Infections and Healing: A Clinician’s Perspective

2Opsonization is a process by which a pathogen or other antigen is covered with antibodies and thereby marked for ingestion and destruction by other immune cells (i.e., phagocytic cells). All types of alcohol can trigger inflammation, though how much inflammation it causes can vary depending on the type of alcohol and amount consumed. Red wine contains polyphenols—antioxidant compounds with anti-inflammatory properties—which suggests it may cause less inflammation than other types of alcohol, such as liquor or beer. Nicotine from cigarettes, chewing tobacco, or any other source can weaken your body’s ability to fight germs. Other chemicals in e-liquids seem to suppress your immune response, especially when you inhale them through vaping.

  • It follows that ILC2 dysregulation may contribute to alcohol-induced impairment of these processes.
  • Alcohol use disorder (AUD) is a chronic brain condition characterized by continued alcohol consumption despite harmful consequences.
  • If you are drinking a lot, stopping or decreasing your alcohol use can also help your chances of not developing severe liver disease.
  • Chronic excessive alcohol consumption causes inflammation in a variety of organs, including the gut, brain and liver.

Similar results have been seen in SIV infection of male nonhuman primates (Bagby, Stoltz et al. 2003, Molina, McNurlan et al. 2006, Poonia, Nelson et al. 2006, Marcondes, Watry et al. 2008). The effects of chronic alcohol exposure are not limited to phenotypic changes in T cells but also include T-cell functions. Among other reactions, LPS injection normally triggers lymphocyte migration out of the circulation and into tissues and the lymphatic system (Percival and Sims 2000). In water- or wine-consuming mice, LPS injection, as expected, led to a 50 percent reduction in the number of lymphocytes in the peripheral blood, indicating their mobilization into tissues. In contrast, the ethanol-consuming mice exhibited no change in the frequency of certain circulating lymphocytes (i.e., CD3 cells) after LPS injection, suggesting that chronic alcohol consumption may potentially impair the ability of lymphocytes to migrate out of circulation (Percival and Sims 2000). One potential explanation for the lack of detrimental effects of wine in this experiment could be the presence of phytochemicals in wine that may be able to overcome ethanol’s harmful impact on immunity.

How Your Immune System Works

The adaptive immune system can be subdivided into cell-mediated immunity, carried out by T cells, and humoral immunity, carried out by B cells. T cells expressing the CD4 T cell co-receptor are known as T helper cells and play a critical role in the activation and maturation of monocytes, cytotoxic T cells and B cells. T cells does alcohol weaken your immune system expressing the CD8 T cell co-receptor are known as cytotoxic T cells and eliminate host cells infected with intracellular pathogens as well as tumor cells. B cells mature into plasma cells that produce antibodies, also known as immunoglobulins (Ig), to eliminate extracellular microorganisms and prevent the spread of infection.

  • This may increase alcohol consumption and risky decisionmaking and decrease behavioral flexibility, thereby promoting and sustaining high levels of drinking.
  • Ethanol consumption by weanling ICR (outbred) mice (adjusted to 6% in their drinking water) for 8 weeks also resulted in 75% fewer CD3+ T cells (Percival and Sims 2000).
  • Inflammation is the body’s immune response to a detected threat, which can have lasting health effects.

Finally, chronic alcohol exposure in utero interferes with normal T-cell and B-cell development, which may increase the risk of infections during both childhood and adulthood. Alcohol’s impact on T cells and B cells increases the risk of infections (e.g., pneumonia, HIV infection, hepatitis C virus infection, and tuberculosis), impairs responses to vaccinations against such infections, exacerbates cancer risk, and interferes with delayed-type hypersensitivity. In contrast to these deleterious effects of heavy alcohol exposure, moderate alcohol consumption may have beneficial effects on the adaptive immune system, including improved responses to vaccination and infection. The molecular mechanisms underlying ethanol’s impact on the adaptive immune system remain poorly understood.

Alcohol and the Adaptive Immune Response

Consuming small amounts of alcohol in moderation or abstaining from alcohol altogether can help reduce inflammation, improve your overall health, and reduce your risk of chronic diseases. Alcohol use disorder (AUD) is a chronic brain condition characterized by continued alcohol consumption despite harmful consequences. If you are struggling with alcohol use disorder or suspect you have an unhealthy relationship with alcohol, you are not alone. Alcohol–immune interactions also may affect the development and progression of certain cancers. Meadows and Zhang discuss specific mechanisms through which alcohol interferes with the body’s immune defense against cancer.

One early study (Lundy et al. 1975) showed defects in cell-mediated immunity in male alcoholic patients admitted for detoxification, in response both to a new antigen and to an antigen to which they had previously been exposed. A more recent study (Smith et al. 2004) reported that a negative correlation existed between the amount of alcohol consumed by the https://ecosoberhouse.com/ participants and the size of DTH skin test responses to a specific antigen (i.e., keyhole limpet hemocyanin). For instance, genetically modified BALB/c mice that carried a TCR specific for the ovalbumin peptide and were fed a diet containing 30 percent ethanol-derived calories exhibited decreased antigen-specific Th1 responses (Waltenbaugh et al. 1998).



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